ea0077p42 | Metabolism, Obesity and Diabetes | SFEBES2021
Martin Claire S
, Kalirai Matthew Singh
, Crastin Ana
, Turner Jason D
, Schiffer Lina
, Gilligan Lorna C
, Taylor Angela E
, Scheel-Toellner Dagmar
, Raza Karim
, Filer Andrew
, Jones Simon W
, Arlt Wiebke
, Hewison Martin
, Hardy Rowan S
Active androgens exert immunomodulatory actions at sites of inflammation and lower levels are implicated in the increased incidence of rheumatoid arthritis (RA) in females. However, inflammatory regulation of intracrine androgen metabolism within cell populations at sites of inflammation remain poorly defined. In this study we characterised immune and stromal cell androgen metabolism in RA patients and assessed their functional significance. Using the online Accelerating Medic...